Poster 2001: Generation a hypoallergenic profilin from amaranthus palmeri pollen
نویسندگان
چکیده
Background Amaranthus pollen grains are known to be highly allergenic and a potential cause of respiratory allergic diseases in many countries. Amaranthus palmeri pollen is an important allergenic source in Mexico; however in our country, there is not reported data about the prevalence of these pollens. The first allergenic profilin was identified from birch pollen allergen (Bet v 2) in 1991. Many studies have been described that patients who developed allergies against profilin from pollen commonly presented cross-reactivity against to vegetable food profilin, in particular to different fruits as nuts, melon, orange, and peach, or to vegetables as zucchini, celery, tomatoes and carrots or also latex. The aim of the study is to clone the profilin from A. palmeri pollen and obtain hypoallergenic profilin variant, this variant could be used as a therapeutic.
منابع مشابه
Major allergen from Amaranthus palmeri pollen is a profilin: Isolation, partial characterisation and IgE recognition.
BACKGROUND Pollens represent a rich source of proteins that are also potential elicitors of IgE-mediated pollen allergy. Sensitisation to panallergens could play an important role in diagnosis and specific immunotherapy, because these molecules are present in different plant pollens and plant foods and have marked structural similarity in different species. Profilins are one of the most common ...
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